Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells.
Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC6172369 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Publications
Dicer affects cisplatin‑mediated apoptosis in epithelial ovarian cancer cells.
Wang Xi X Chen Hui H Wen Yiping Y Yang Xiaoxin X Han Qing Q Jiang Ping P Huang Zaiju Z Cai Jing J Wang Zehua Z
Molecular medicine reports 20180904 5
Dicer is an essential enzyme that processes micro (mi)-RNA precursors into mature miRNAs, and serves a critical role in cancer development and progression by regulating gene expression. However, the role of Dicer in cisplatin‑mediated apoptosis and chemotherapy resistance in epithelial ovarian cancer (EOC) cells is poorly understood. In the present study, Dicer was expressed at low levels in cisplatin‑resistant A2780 cells when compared with parental cells. In addition, knocking down Dicer using ...[more]
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