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Endothelin-receptor antagonists in the management of pulmonary arterial hypertension: where do we stand?


ABSTRACT: Pulmonary arterial hypertension, a disease largely neglected until a few decades ago, is presently the object of intense studies by several research teams. Despite considerable progress, pulmonary arterial hypertension remains a major clinical problem, because it is not always easy to diagnose, treat, and prevent. The disease was considered incurable until the late 1990s, when Epoprostenol was introduced as the first tool against this illness. More recently, therapy for pulmonary arterial hypertension gained momentum after publication of the SERAPHIN and AMBITION trials, which also highlighted the importance of upfront therapy. This review also focuses on recent substudies from these trials and progress in drugs targeting the endothelin pathway. Future perspectives with regard to endothelin-receptor antagonists are also discussed.

SUBMITTER: Correale M 

PROVIDER: S-EPMC6174907 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Endothelin-receptor antagonists in the management of pulmonary arterial hypertension: where do we stand?

Correale Michele M   Ferraretti Armando A   Monaco Ilenia I   Grazioli Davide D   Di Biase Matteo M   Brunetti Natale Daniele ND  

Vascular health and risk management 20181004


Pulmonary arterial hypertension, a disease largely neglected until a few decades ago, is presently the object of intense studies by several research teams. Despite considerable progress, pulmonary arterial hypertension remains a major clinical problem, because it is not always easy to diagnose, treat, and prevent. The disease was considered incurable until the late 1990s, when Epoprostenol was introduced as the first tool against this illness. More recently, therapy for pulmonary arterial hypert  ...[more]

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