Ontology highlight
ABSTRACT:
SUBMITTER: Aronson JK
PROVIDER: S-EPMC6175306 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Aronson Jeffrey K JK La Caze Adam A Kelly Michael P MP Parkkinen Veli-Pekka VP Williamson Jon J
Journal of evaluation in clinical practice 20180611 5
The role of mechanistic evidence tends to be under-appreciated in current evidence-based medicine (EBM), which focusses on clinical studies, tending to restrict attention to randomized controlled studies (RCTs) when they are available. The EBM+ programme seeks to redress this imbalance, by suggesting methods for evaluating mechanistic studies alongside clinical studies. Drug approval is a problematic case for the view that mechanistic evidence should be taken into account, because RCTs are almos ...[more]