Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC6175864 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Liu Mingdong M Zeng Taoling T Zhang Xin X Liu Chunyan C Wu Zhihui Z Yao Luming L Xie Changchuan C Xia Hui H Lin Qi Q Xie Liping L Zhou Dawang D Deng Xianming X Chan Hong-Lin HL Zhao Tong-Jin TJ Wang Hong-Rui HR
Nature communications 20181008 1
DNA damage can induce autophagy; however, the underlying mechanism remains largely unknown. Here we report that DNA damage leads to autophagy through ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex and subsequent mTORC1 inhibition. DNA damage caused by ultraviolet light (UV) or alkylating agent methyl methanesulphonate (MMS) results in phosphorylation of small GTPase RhoB by Chk1. Phosphorylation of RhoB enhances its interaction with the TSC2, and promotes its sumoylation by PIAS1, w ...[more]