Ontology highlight
ABSTRACT:
SUBMITTER: Marin-Mogollon C
PROVIDER: S-EPMC6175877 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Marin-Mogollon Catherin C van de Vegte-Bolmer Marga M van Gemert Geert-Jan GJ van Pul Fiona J A FJA Ramesar Jai J Othman Ahmad Syibli AS Kroeze Hans H Miao Jun J Cui Liwang L Williamson Kim C KC Sauerwein Robert W RW Janse Chris J CJ Khan Shahid M SM
Scientific reports 20181008 1
Two members of 6-cysteine (6-cys) protein family, P48/45 and P230, are important for gamete fertility in rodent and human malaria parasites and are leading transmission blocking vaccine antigens. Rodent and human parasites encode a paralog of P230, called P230p. While P230 is expressed in male and female parasites, P230p is expressed only in male gametocytes and gametes. In rodent malaria parasites this protein is dispensable throughout the complete life-cycle; however, its function in P. falcip ...[more]