Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC6175900 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Wang Sheng S Ma Jianzhu J Zhang Wei W Shen John Paul JP Huang Justin J Peng Jian J Ideker Trey T
Nature communications 20181008 1
Many recent efforts to analyze cancer genomes involve aggregation of mutations within reference maps of molecular pathways and protein networks. Here, we find these pathway studies are impeded by molecular interactions that are functionally irrelevant to cancer or the patient's tumor type, as these interactions diminish the contrast of driver pathways relative to individual frequently mutated genes. This problem can be addressed by creating stringent tumor-specific networks of biophysical protei ...[more]