Ontology highlight
ABSTRACT:
SUBMITTER: Mahn M
PROVIDER: S-EPMC6175909 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Mahn Mathias M Gibor Lihi L Patil Pritish P Cohen-Kashi Malina Katayun K Oring Shir S Printz Yoav Y Levy Rivka R Lampl Ilan I Yizhar Ofer O
Nature communications 20181008 1
Optogenetic silencing allows time-resolved functional interrogation of defined neuronal populations. However, the limitations of inhibitory optogenetic tools impose stringent constraints on experimental paradigms. The high light power requirement of light-driven ion pumps and their effects on intracellular ion homeostasis pose unique challenges, particularly in experiments that demand inhibition of a widespread neuronal population in vivo. Guillardia theta anion-conducting channelrhodopsins (GtA ...[more]