Ontology highlight
ABSTRACT:
SUBMITTER: Moore YE
PROVIDER: S-EPMC6176565 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Moore Yvonne E YE Deeb Tarek Z TZ Chadchankar Heramb H Brandon Nicholas J NJ Moss Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20180917 40
The type 2 K<sup>+</sup>/Cl<sup>-</sup> cotransporter (KCC2) allows neurons to maintain low intracellular levels of Cl<sup>-</sup>, a prerequisite for efficient synaptic inhibition. Reductions in KCC2 activity are evident in epilepsy; however, whether these deficits directly contribute to the underlying pathophysiology remains controversial. To address this issue, we created knock-in mice in which threonines 906 and 1007 within KCC2 have been mutated to alanines (KCC2-T906A/T1007A), which preven ...[more]