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Association between lower estimated premorbid intelligence quotient and smoking behavior in patients with schizophrenia.

ABSTRACT: Aim:We aimed to investigate the involvement of premorbid intelligence quotient in higher prevalence of smoking in patients with schizophrenia. Methods:Participants included 190 patients with schizophrenia (mean?±?standard deviation age: 37.7?±?10.8?years; 88 males and 102 females) and 312 healthy individuals (mean?±?standard deviation age: 38.1?±?13.8; 166 males and 146 females), matched for age, sex, and ethnicity (Japanese). Premorbid intelligence quotient was estimated using the Japanese Adult Reading Test and distress symptoms were assessed using the Hopkins Symptom Check List. Current smoking information was collected according to self-declarations. Results:As expected, the smoking rate was higher, while mean education level and Japanese Adult Reading Test scores were significantly lower, in patients with schizophrenia than in healthy individuals (p?

SUBMITTER: Hidese S

PROVIDER: S-EPMC6176847 | biostudies-other | 2019 Mar

REPOSITORIES: biostudies-other

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Association between lower estimated premorbid intelligence quotient and smoking behavior in patients with schizophrenia.

Hidese Shinsuke S Matsuo Junko J Ishida Ikki I Hiraishi Moeko M Teraishi Toshiya T Ota Miho M Hattori Kotaro K Kunugi Hiroshi H

Schizophrenia research. Cognition 20181009

<h4>Aim</h4>We aimed to investigate the involvement of premorbid intelligence quotient in higher prevalence of smoking in patients with schizophrenia.<h4>Methods</h4>Participants included 190 patients with schizophrenia (mean ± standard deviation age: 37.7 ± 10.8 years; 88 males and 102 females) and 312 healthy individuals (mean ± standard deviation age: 38.1 ± 13.8; 166 males and 146 females), matched for age, sex, and ethnicity (Japanese). Premorbid intelligence quotient was estimated using th ...[more]

PMID: 30310770

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Project description:Introduction: Lateralization in brain function has been associated with age and sex in previous work; however, there has been less focus on lateralization of functional networks during development. Aim: We aim to examine laterality in typical development; a clearer understanding of how and to what extent functional brain networks are lateralized in typical development may eventually prove to hold predictive information in psychopathology. Material and Methods: In this study, we examine the lateralization of resting-state networks assessed with a group-independent component analysis using resting-state functional magnetic resonance imaging from a large cohort consisting of 774 children, ages 6-10 years. This is an extension of our previous work on normal aging in adults, where we now assess whether there are similar patterns in children. Results: Unlike the results from our study of healthy aging in adults, which showed a decrease in laterality with increasing age, in this study we found both decreases and increases in lateralization in multiple networks with development. For example, auditory and sensorimotor regions had greater bilateral connectivity with development, whereas regions including the dorsolateral frontal cortex (Brodmann area left 9 and left 46) showed an increase in left lateralization with development. Conclusion: Our findings support a complex, nonlinear association between laterality and age in school-age children, a time when brain function and structure are developing rapidly. We also found brain networks in which laterality was significantly associated with sex, handedness, and intelligence quotient, but we did not find any significant association with behavioral scores. Impact statement Lateralization in brain function has been associated with age and sex in several previous studies; however, there has been less focus on lateralization of functional networks during development. A clearer understanding of how and to what extent functional brain networks are lateralized in typical development may eventually prove to hold predictive information in psychopathology. In this study, we examine the lateralization of resting-state networks assessed with a group-independent component analysis using resting-state functional magnetic resonance imaging from a large cohort consisting of 774 children, ages 6-10 years.

Dataset Information

Association between lower estimated premorbid intelligence quotient and smoking behavior in patients with schizophrenia.

Publications

Association between lower estimated premorbid intelligence quotient and smoking behavior in patients with schizophrenia.

Similar Datasets

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