The Neuropsychiatric and Motor Profile of GBA-Associated Parkinson's Disease: A Review.

ABSTRACT: Background:Cognitive and motor decline, along with psychiatric symptoms, have a major impact on independence, nursing home admission, caregiver burden, and mortality in Parkinson's disease (PD). The single most common genetic risk factor for developing PD is a mutation in the glucocerebrosidase (GBA) gene. Methods:This work is a literature review regarding "GBA" and "Parkinson's disease" as conducted by PubMed search. Results:There is a higher prevalence of cognitive decline and more rapid trajectory of disease progression in PD-GBA carriers, compared to noncarriers. PD-GBA carriers also have domain-specific cognitive impairment, particularly in visual memory tasks. PD-GBA carriers may also have a more aggressive motor phenotype than noncarriers. Conclusions:Early identification of PD-GBA carriers may lead to targeted therapies and development of new treatments.

SUBMITTER: Pal G 

PROVIDER: S-EPMC6178756 | biostudies-other | 2016 Jan-Feb

REPOSITORIES: biostudies-other