?T-catenin: A developmentally dispensable, disease-linked member of the ?-catenin family.
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ABSTRACT:
SUBMITTER: Chiarella SE
PROVIDER: S-EPMC6179130 | biostudies-other | 2018
REPOSITORIES: biostudies-other
Publications
αT-catenin: A developmentally dispensable, disease-linked member of the α-catenin family.
Chiarella Sergio E SE Rabin Erik E EE Ostilla Lorena A LA Flozak Annette S AS Gottardi Cara J CJ
Tissue barriers 20180510 2
α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic ...[more]
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