Unknown

Dataset Information

0

Factors driving effective population size and pan-genome evolution in bacteria.


ABSTRACT: BACKGROUND:Knowledge of population-level processes is essential to understanding the efficacy of selection operating within a species. However, attempts at estimating effective population sizes (Ne) are particularly challenging in bacteria due to their extremely large census populations sizes, varying rates of recombination and arbitrary species boundaries. RESULTS:In this study, we estimated Ne for 153 species (152 bacteria and one archaeon) defined under a common framework and found that ecological lifestyle and growth rate were major predictors of Ne; and that contrary to theoretical expectations, Ne was unaffected by recombination rate. Additionally, we found that Ne shapes the evolution and diversity of total gene repertoires of prokaryotic species. CONCLUSION:Together, these results point to a new model of genome architecture evolution in prokaryotes, in which pan-genome sizes, not individual genome sizes, are governed by drift-barrier evolution.

SUBMITTER: Bobay LM 

PROVIDER: S-EPMC6186134 | biostudies-other | 2018 Oct

REPOSITORIES: biostudies-other

altmetric image

Publications

Factors driving effective population size and pan-genome evolution in bacteria.

Bobay Louis-Marie LM   Ochman Howard H  

BMC evolutionary biology 20181012 1


<h4>Background</h4>Knowledge of population-level processes is essential to understanding the efficacy of selection operating within a species. However, attempts at estimating effective population sizes (Ne) are particularly challenging in bacteria due to their extremely large census populations sizes, varying rates of recombination and arbitrary species boundaries.<h4>Results</h4>In this study, we estimated Ne for 153 species (152 bacteria and one archaeon) defined under a common framework and f  ...[more]

Similar Datasets

| S-EPMC4869408 | biostudies-literature
| S-EPMC3457769 | biostudies-literature
| S-EPMC5520154 | biostudies-literature
| S-EPMC4709115 | biostudies-literature
| S-EPMC4576703 | biostudies-literature
| S-EPMC1208362 | biostudies-other
| S-EPMC5068858 | biostudies-literature
| S-EPMC4330256 | biostudies-literature
| S-EPMC9068888 | biostudies-literature
| S-EPMC7462614 | biostudies-literature