Ontology highlight
ABSTRACT:
SUBMITTER: Nissen SK
PROVIDER: S-EPMC6189090 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Nissen Sara Konstantin SK Christiansen Mette M Helleberg Marie M Kjær Kathrine K Jørgensen Sofie Eg SE Gerstoft Jan J Katzenstein Terese L TL Benfield Thomas T Kronborg Gitte G Larsen Carsten S CS Laursen Alex A Pedersen Gitte G Jakobsen Martin R MR Tolstrup Martin M Mogensen Trine H TH
Scientific reports 20181015 1
Common CCR5-∆32 and HLA alleles only explain a minority of the HIV long-term non-progressor (LTNP) and elite controller (EC) phenotypes. To identify rare genetic variants contributing to the slow disease progression phenotypes, we performed whole exome sequencing (WES) on seven LTNPs and four ECs. HLA and CCR5 allele status, total HIV DNA reservoir size, as well as variant-related functional differences between the ECs, LTNPs, and eleven age- and gender-matched HIV-infected non-controllers on an ...[more]