Detection of early neoplasia in Barrett's esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.
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ABSTRACT:
SUBMITTER: Neves AA
PROVIDER: S-EPMC6193410 | biostudies-other | 2018 Jun
REPOSITORIES: biostudies-other
Publications
Detection of early neoplasia in Barrett's esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue.
Neves André A AA Di Pietro Massimiliano M O'Donovan Maria M Waterhouse Dale J DJ Bohndiek Sarah E SE Brindle Kevin M KM Fitzgerald Rebecca C RC
Endoscopy 20180117 6
<h4>Background and study aims</h4>Endoscopic surveillance for Barrett's esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical scattering. We assessed the feasibility of a topically applied NIR dye-labeled lectin for the detection of early neoplasia in BE in an ex vivo setting.<h4>Methods</h4>Consecutive patients undergoing endoscopic mucosal resection (EMR) for BE-related early neoplasia were r ...[more]
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