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Effect of sun exposure on cognitive function among elderly individuals in Northeast China.

ABSTRACT: Background:Previous findings on the relationship between serum 25-hydroxyvitamin D [25(OH)D] level and cognitive impairment have been inconsistent. One reason is that serum 25(OH)D has a relatively short half-life, but the development of cognitive impairment is a long-term process. Skin exposure to solar ultraviolet radiation is the primary source of vitamin D synthesis. For this study, we hypothesized that people with different sun exposure behaviors would have different cognitive functions. Methods:This study included 1,192 rural-dwelling elders in People's Republic of China whose sun exposure behaviors, including the duration of outdoor activities, use of sun protection, and time of day participants engaged in outdoor activities, were collected. Their global cognitive function was assessed by Mini-Mental State Examination (MMSE). Partitioning cluster analysis was used to classify participants into groups based on their sun exposure behaviors. Ordinal logistic regression analysis was used to examine the association between sun exposure and cognitive function. Results:The participants were divided into high-, medium-, and low-sun-exposure groups by cluster analysis. The participants in the high-sun-exposure group had the longest sun exposure time, reported the least sun-protective behaviors, and usually spent time outdoors in the morning (8:00-11:00) and afternoon (13:00-16:00). The participants in the low-sun-exposure group had the shortest sun exposure time, had the most positive sun-protective behaviors, and mainly spent time outdoors in the early morning (6:00-8:00) and late afternoon (16:00-18:00). After adjusting for potential confounders, participants with habitually high sun exposure were more likely to have higher MMSE score (25.4) than those with habitually low sun exposure (MMSE score =24.4). Conclusion:Long-term high sun exposure is positively related with better cognitive functioning.

SUBMITTER: Gao Q

PROVIDER: S-EPMC6202005 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Effect of sun exposure on cognitive function among elderly individuals in Northeast China.

Gao Qian Q Luan Dechun D Wang Xue X Xin Shimeng S Liu Yang Y Li Jing J

Clinical interventions in aging 20181018

<h4>Background</h4>Previous findings on the relationship between serum 25-hydroxyvitamin D [25(OH)D] level and cognitive impairment have been inconsistent. One reason is that serum 25(OH)D has a relatively short half-life, but the development of cognitive impairment is a long-term process. Skin exposure to solar ultraviolet radiation is the primary source of vitamin D synthesis. For this study, we hypothesized that people with different sun exposure behaviors would have different cognitive funct ...[more]

PMID: 30425462

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Project description:BACKGROUND:With the disappointing outcomes of clinical trials on patients with Alzheimer's disease or mild cognitive impairment (MCI), there is increasing attention to understanding cognitive decline in normal elderly individuals, with the goal of identifying subjects who are most susceptible to imminent cognitive impairment. PURPOSE/HYPOTHESIS:To evaluate the potential of cerebral blood flow (CBF) as a biomarker by investigating the relationship between CBF at baseline and cognition at follow-up. STUDY TYPE:Prospective longitudinal study with a 4-year time interval. POPULATION:309 healthy subjects aged 20-89 years old. FIELD STRENGTH/SEQUENCE:3T pseudo-continuous-arterial-spin-labeling MRI. ASSESSMENT:CBF at baseline and cognitive assessment at both baseline and follow-up. STATISTICAL TESTS:Linear regression analyses with age, systolic blood pressure, physical activity, and baseline cognition as covariates. RESULTS:Linear regression analyses revealed that whole-brain CBF at baseline was predictive of general fluid cognition at follow-up. This effect was observed in the older group (age ?54 years, ??=?0.221, P?=?0.004), but not in younger or entire sample (??=?0.018, P?=?0.867 and ??=?0.089, P?=?0.098, respectively). Among major brain lobes, frontal CBF had the highest sensitivity in predicting future cognition, with a significant effect observed for fluid cognition (??=?0.244 P?=?0.001), episodic memory (??=?0.294, P?=?0.001), and reasoning (??=?0.186, P?=?0.027). These associations remained significant after accounting for baseline cognition. Voxelwise analysis revealed that medial frontal cortex and anterior cingulate cortex, part of the default mode network (DMN), are among the most important regions in predicting fluid cognition. DATA CONCLUSION:In a healthy aging cohort, CBF can predict general cognitive ability as well as specific domains of cognitive function. LEVEL OF EVIDENCE:1 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2018;48:449-458.

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Effect of sun exposure on cognitive function among elderly individuals in Northeast China.

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Effect of sun exposure on cognitive function among elderly individuals in Northeast China.

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