A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma.
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ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC6203798 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Publications
A crucial role of the PD-1H coinhibitory receptor in suppressing experimental asthma.
Liu Huafeng H Li Xin X Hu Li L Zhu Min M He Bailin B Luo Liqun L Chen Lieping L
Cellular & molecular immunology 20170508 9
Programmed death one homolog (PD-1H) is a cell surface molecule of the B7/CD28 immune modulatory gene family. Although PD-1H has been shown to function as a coinhibitory receptor on T cells to limit naive T-cell activation and proliferation, its role in the regulation of the T-cell response to allergens is unknown. We report here that genetic ablation or blockade of PD-1H drastically promotes pulmonary inflammation with massive accumulation of eosinophils in a mouse model of experimental asthma, ...[more]
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