Ontology highlight
ABSTRACT:
SUBMITTER: Osakada T
PROVIDER: S-EPMC6203846 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Osakada Takuya T Ishii Kentaro K KK Mori Hiromi H Eguchi Ryo R Ferrero David M DM Yoshihara Yoshihiro Y Liberles Stephen D SD Miyamichi Kazunari K Touhara Kazushige K
Nature communications 20181026 1
Mating drive is balanced by a need to safeguard resources for offspring, yet the neural basis for negative regulation of mating remains poorly understood. In rodents, pheromones critically regulate sexual behavior. Here, we observe suppression of adult female sexual behavior in mice by exocrine gland-secreting peptide 22 (ESP22), a lacrimal protein from juvenile mice. ESP22 activates a dedicated vomeronasal receptor, V2Rp4, and V2Rp4 knockout eliminates ESP22 effects on sexual behavior. Genetic ...[more]