Ontology highlight
ABSTRACT:
SUBMITTER: Jungnickel MK
PROVIDER: S-EPMC6203878 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Jungnickel Melissa K MK Sutton Keith A KA Baker Mark A MA Cohen Michael G MG Sanderson Michael J MJ Florman Harvey M HM
Biology of reproduction 20181001 4
Enkurin was identified initially in mouse sperm where it was suggested to act as an intracellular adaptor protein linking membrane calcium influx to intracellular signaling pathways. In order to examine the function of this protein, a targeted mutation was introduced into the mouse Enkurin gene. Males that were homozygous for this mutated allele were subfertile. This was associated with lower rates of sperm transport in the female reproductive tract, including reduced entry into the oviduct and ...[more]