TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro.
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ABSTRACT:
SUBMITTER: Castiglioni S
PROVIDER: S-EPMC6212439 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Publications
TRPM7 and MagT1 in the osteogenic differentiation of human mesenchymal stem cells in vitro.
Castiglioni Sara S Romeo Valentina V Locatelli Laura L Cazzaniga Alessandra A Maier Jeanette A M JAM
Scientific reports 20181101 1
Mesenchymal stem cells are fundamental for bone formation and repair since they respond to microenvironmental stimuli by undergoing osteogenic differentiation. We show that the kinase and cation channel TRPM7 and the magnesium transporter MagT1 have a role in harmonizing the osteogenic differentiation of human mesenchymal stem cells. TRPM7 and MagT1 are upregulated in osteogenic differentiation and silencing either one accelerates osteogenic differentiation, partly through the activation of auto ...[more]
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