Ontology highlight
ABSTRACT:
SUBMITTER: Quinn JL
PROVIDER: S-EPMC6214126 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Quinn James L JL Axtell Robert C RC
International journal of molecular sciences 20181019 10
Multiple sclerosis (MS) is an autoimmune disorder where both T cells and B cells are implicated in pathology. However, it remains unclear how these two distinct populations cooperate to drive disease. There is ample evidence from studies in both MS patients and mouse models that Th17, B cells, and follicular T helper (TFH) cells contribute to disease. This review article describes the literature that identifies mechanisms by which Th17, TFH, and B cells cooperatively drive disease activity in MS ...[more]