Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling.
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ABSTRACT:
SUBMITTER: Yang M
PROVIDER: S-EPMC6214856 | biostudies-other | 2018 Oct
REPOSITORIES: biostudies-other
Publications
Ascorbic acid inhibits senescence in mesenchymal stem cells through ROS and AKT/mTOR signaling.
Yang Mengkai M Teng Songsong S Ma Chunhui C Yu Yinxian Y Wang Peilin P Yi Chengqing C
Cytotechnology 20180518 5
Mesenchymal stem cell (MSC) aging seriously affects its function in stem cell transplantation for treatment. Extensive studies have focused on how to inhibit senescence in MSCs. However, the mechanism of senescence in MSC was not clear. In this study, we used D-galactose to induce MSC aging. Then we found that the number of aging cells was increased compared with untreated MSCs. We discovered that ascorbic acid could inhibit the production of reactive oxygen species (ROS) and activation of AKT/m ...[more]
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