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Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.

ABSTRACT: Objective:Individuals with multiple metabolic risk factors often experience concomitant sleep-disordered breathing (SDB). We aimed to determine the associations of SDB with individual components of metabolic syndrome independent of obesity. Methods:A cross-sectional study was conducted in 1137 employees aged 30-64 years. Apnea-hypopnea index (AHI) was assessed using a portable monitor for obstructive sleep apnea by admission. Of these, 451 participants took an oral glucose tolerance test to assess homeostatic model assessment of insulin resistance (HOMA-IR) and Matsuda insulin sensitivity index (ISI). Results:The odds ratio (OR) of the highest category of the AHI (≥15 episodes per hour) compared to the lowest one (<5 episodes per hour) was significantly elevated for hypertension, for hypertriglyceridemia, and for low HDL-cholesterolemia when adjusted for age, sex, and alcohol and smoking status (p < 0.05). After further adjustment for body mass index (BMI) or waist circumference, the associations for hypertension still remained statistically significant (p < 0.05) while those for hypertriglyceridemia and low HDL-cholesterolemia were no longer significant. The association between higher insulin resistance as assessed by HOMA-IR and Matsuda ISI and higher categories of the AHI was also lost after adjustment for BMI. Conclusion:Obesity was a strong confounding factor in the association between SDB and most metabolic risk factors including insulin resistance, except for hypertension. Further longitudinal study is needed to examine the temporal or causal relationships between SDB and metabolic risk factors. This trial is registered with UMIN-CTR UMIN000028067.

SUBMITTER: Wakabayashi Y

PROVIDER: S-EPMC6217749 | biostudies-other | 2018

REPOSITORIES: biostudies-other

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Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.

Wakabayashi Yusuke Y Oka Rie R Nakaya Masako M Karashima Shigehiro S Kometani Mitsuhiro M Sakurai Masaru M Yoshimura Kenichi K Yoneda Takashi T

Journal of diabetes research 20181022

<h4>Objective</h4>Individuals with multiple metabolic risk factors often experience concomitant sleep-disordered breathing (SDB). We aimed to determine the associations of SDB with individual components of metabolic syndrome independent of obesity.<h4>Methods</h4>A cross-sectional study was conducted in 1137 employees aged 30-64 years. Apnea-hypopnea index (AHI) was assessed using a portable monitor for obstructive sleep apnea by admission. Of these, 451 participants took an oral glucose toleran ...[more]

PMID: 30426019

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Project description:BackgroundSleep-disordered breathing (SDB) is a common syndrome in children, related to their immune responses, cardiovascular function, and neurocognitive function. This study aimed to determine the prevalence of SDB among children in Wuxi, China, and to evaluate the protective and risk factors of SDB in children.MethodsA cross-sectional study was conducted on children attending different schools across Wuxi, China, aged 3-14?years old. Of a total of 5630 questionnaires distributed to the parents of the children, 3997 (71.0%) were deemed to be valid. The data on the general sociodemographic factors, children's allergy and sleep characteristics, and the parents' sleep characteristics were also collected. The Paediatric Sleep Questionnaire (PSQ) score was used to identify children at high risk of SDB. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by logistic regression.ResultsThe prevalence of SDB in this cohort was 13.4% (N?=?534). SDB prevalence significantly differed in children with asthma (28.2% vs. 12.8%, P?<?0.001), eczema (19.0% vs. 10.0%, P?<?0.001), urticaria (16.4% vs. 12.9%, P?<?0.01) and rhinitis (21.4% vs. 10.7%, P?<?0.001). No significant differences were found in SDB prevalence with respect to pillow material or quilt material. On multivariate logistic regression analysis, asthma (OR 1.986 (95% CI 1.312-3.007), P?<?0.01), eczema (OR 1.675 (95% CI 1.377-2.037), P?<?0.001), rhinitis (OR 1.998 (95% CI 1.635-2.441), suffered from familial sleep sickness (OR 2.416 (95% CI 1.975-2.955), P?<?0.001) and whose mothers slept for a shorter duration (6?h-8?h: OR 1.370 (95% CI 1.089-1.724), P?<?0.01; <6?h: OR 3.385(95% CI 2.098-5.461), P?<?0.001) increased the odds of having SDB. The incidence of SDB significantly decreased with children's age (6-11?years old: 0R 0.768 (95% CI 0.597-0.989), P?<?0.05; 12-14?years old: OR 0.691 (95% CI 0.530-0.901), P?<?0.01).ConclusionThe results of this study demonstrated that atopic diseases (asthma, eczema, and rhinitis) and family sleep habits were risk factors for SDB in children in Wuxi, China.

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Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.

Publications

Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity.

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