Ontology highlight
ABSTRACT:
SUBMITTER: Mateu N
PROVIDER: S-EPMC6220872 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Mateu Natalia N Kidd Sarah L SL Kalash Leen L Sore Hannah F HF Madin Andrew A Bender Andreas A Spring David R DR
Chemistry (Weinheim an der Bergstrasse, Germany) 20180813 51
N-containing quaternary stereocenters represent important motifs in medicinal chemistry. However, due to their inherently sterically hindered nature, they remain underrepresented in small molecule screening collections. As such, the development of synthetic routes to generate small molecules that incorporate this particular feature are highly desirable. Herein, we describe the diversity-oriented synthesis (DOS) of a diverse collection of structurally distinct small molecules featuring this three ...[more]