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Acylphloroglucinol Derivatives from Garcinia multiflora with Anti-Inflammatory Effect in LPS-Induced RAW264.7 Macrophages.

ABSTRACT: Two new acylphloroglucinol derivatives, 13,14-didehydroxygarcicowin C (1) and 13,14-didehydroxyisoxanthochymol (2), have been isolated from the stems of Garcinia multiflora, together with seven known compounds (3?9). The structures of new compounds 1 and 2 were elucidated by MS and extensive 1D/2D NMR spectroscopic analyses. Among the isolates, 13,14-didehydroxy-isoxanthochymol (2) and sampsonione B (3) exhibited inhibition against lipopolysaccharide (LPS)-induced NF-?B activation in macrophages at 30 ?M with relative luciferase activity values (inhibitory %) of 0.75 ± 0.03 (24 ± 4%) and 0.12 ± 0.03 (88 ± 4%), respectively. Additionally, sampsonione B (3) reduced LPS-induced nitric oxide (NO) production in murine RAW264.7 macrophages and did not induce cytotoxicity against RAW 264.7 cells after 24 h treatment. Compound 3 is worth further investigation and may be expectantly developed as an anti-inflammatory drug candidate.

SUBMITTER: Cheng LY 

PROVIDER: S-EPMC6222856 | biostudies-other | 2018 Oct

REPOSITORIES: biostudies-other

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Acylphloroglucinol Derivatives from <i>Garcinia multiflora</i> with Anti-Inflammatory Effect in LPS-Induced RAW264.7 Macrophages.

Cheng Lin-Yang LY   Tsai Yun-Chen YC   Fu Shu-Ling SL   Cheng Ming-Jen MJ   Sung Ping-Jyun PJ   Chung Mei-Ing MI   Chen Jih-Jung JJ  

Molecules (Basel, Switzerland) 20181010 10

Two new acylphloroglucinol derivatives, 13,14-didehydroxygarcicowin C (<b>1</b>) and 13,14-didehydroxyisoxanthochymol (<b>2</b>), have been isolated from the stems of <i>Garcinia multiflora</i>, together with seven known compounds (<b>3</b>⁻<b>9</b>). The structures of new compounds <b>1</b> and <b>2</b> were elucidated by MS and extensive 1D/2D NMR spectroscopic analyses. Among the isolates, 13,14-didehydroxy-isoxanthochymol (<b>2</b>) and sampsonione B (<b>3</b>) exhibited inhibition against l  ...[more]