Ontology highlight
ABSTRACT:
SUBMITTER: Qian Y
PROVIDER: S-EPMC6222860 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Qian Yajie Y Gao Pin P Xue Gang G Liu Zhenhong Z Chen Jiabin J
Molecules (Basel, Switzerland) 20180813 8
The oxidation of cefalexin (CFX), a commonly used cephalosporin antibiotic, was investigated by permanganate (PM) in water. Apparent second-order rate constant of the reaction between CFX and PM was determined to be 12.71 ± (1.62) M<sup>-1</sup>·s<sup>-1</sup> at neutral pH. Lower pH was favorable for the oxidation of CFX by PM. The presence of Cl<sup>-</sup> and HCO₃<sup>-</sup> could enhance PM-induced oxidation of CFX, whereas HA had negligible effect on CFX oxidation by PM. PM-induced oxidat ...[more]