Ontology highlight
ABSTRACT:
SUBMITTER: Gulati NM
PROVIDER: S-EPMC6223124 | biostudies-other | 2018 Aug
REPOSITORIES: biostudies-other
Gulati Neetu M NM Stewart Phoebe L PL Steinmetz Nicole F NF
Molecular pharmaceutics 20180515 8
Nanoparticle delivery systems offer advantages over free drugs, in that they increase solubility and biocompatibility. Nanoparticles can deliver a high payload of therapeutic molecules while limiting off-target side effects. Therefore, delivery of an existing drug with a nanoparticle frequently results in an increased therapeutic index. Whether of synthetic or biologic origin, nanoparticle surface coatings are often required to reduce immune clearance and thereby increase circulation times allow ...[more]