Ontology highlight
ABSTRACT:
SUBMITTER: Cannon L
PROVIDER: S-EPMC6224063 | biostudies-other | 2018
REPOSITORIES: biostudies-other
PloS one 20181108 11
Clinical trials are necessary in order to develop treatments for diseases; however, they can often be costly, time consuming, and demanding to the patients. This paper summarizes several common methods used for optimal design that can be used to address these issues. In addition, we introduce a novel method for optimizing experiment designs applied to HIV 2-LTR clinical trials. Our method employs Bayesian techniques to optimize the experiment outcome by maximizing the Expected Kullback-Leibler D ...[more]