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Naturally occurring compounds as pancreatic cancer therapeutics.

ABSTRACT: Naturally occurring small molecule compounds have long been in the spotlight of pancreatic cancer research as potential therapeutics to prevent cancer progression and sensitize chemoresistant tumors. The hope is that terminal pancreatic cancer patients receiving aggressive chemotherapy can benefit from an increase in treatment efficacy without adding further toxicity by way of utilizing natural compounds. While preclinical studies on a number of natural compounds, such as resveratrol, curcumin, rapalogs and cannabinoids, show promising preclinical results, little has translated into clinical practice, though a number of other compounds hold clinical potential. Nevertheless, recent advances in compound formulation may increase the clinical utility of these compounds.

SUBMITTER: Lohse I

PROVIDER: S-EPMC6226042 | biostudies-other | 2018 Oct

REPOSITORIES: biostudies-other

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Naturally occurring compounds as pancreatic cancer therapeutics.

Lohse Ines I Wildermuth Erin E Brothers Shaun P SP

Oncotarget 20181023 83

Naturally occurring small molecule compounds have long been in the spotlight of pancreatic cancer research as potential therapeutics to prevent cancer progression and sensitize chemoresistant tumors. The hope is that terminal pancreatic cancer patients receiving aggressive chemotherapy can benefit from an increase in treatment efficacy without adding further toxicity by way of utilizing natural compounds. While preclinical studies on a number of natural compounds, such as resveratrol, curcumin, ...[more]

PMID: 30459936

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Naturally occurring compounds as pancreatic cancer therapeutics.

Publications

Naturally occurring compounds as pancreatic cancer therapeutics.

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