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Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats.

ABSTRACT: BACKGROUND:Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of

SUBMITTER: Shih CH 

PROVIDER: S-EPMC6234801 | biostudies-other | 2018 Nov

REPOSITORIES: biostudies-other

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Chronic pulmonary exposure to traffic-related fine particulate matter causes brain impairment in adult rats.

Shih Chi-Hsiang CH   Chen Jen-Kun JK   Kuo Li-Wei LW   Cho Kuan-Hung KH   Hsiao Ta-Chih TC   Lin Zhe-Wei ZW   Lin Yi-Syuan YS   Kang Jiunn-Horng JH   Lo Yu-Chun YC   Chuang Kai-Jen KJ   Cheng Tsun-Jen TJ   Chuang Hsiao-Chi HC  

Particle and fibre toxicology 20181109 1

<h4>Background</h4>Effects of air pollution on neurotoxicity and behavioral alterations have been reported. The objective of this study was to investigate the pathophysiology caused by particulate matter (PM) in the brain. We examined the effects of traffic-related particulate matter with an aerodynamic diameter of < 1 μm (PM<sub>1</sub>), high-efficiency particulate air (HEPA)-filtered air, and clean air on the brain structure, behavioral changes, brainwaves, and bioreactivity of the brain (cor  ...[more]