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Severe de novo Ulcerative Colitis following Ixekizumab Therapy.

ABSTRACT: Ixekizumab is a selective monoclonal antibody targeting interleukin-17A, approved for the treatment of chronic plaque psoriasis. It has rarely been associated with inflammatory bowel disease (IBD) in randomized trials only. We report a unique case of severe new-onset ulcerative colitis in a young male complicated by cytomegalovirus infection who was on ixekizumab therapy for plaque psoriasis. We recommend that clinicians should exercise caution before prescribing ixekizumab as it seems to induce and exacerbate IBD.

SUBMITTER: Philipose J 

PROVIDER: S-EPMC6244035 | biostudies-other | 2018 Sep-Dec

REPOSITORIES: biostudies-other

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Severe de novo Ulcerative Colitis following Ixekizumab Therapy.

Philipose Jobin J   Ahmed Moiz M   Idiculla Pretty S PS   Mulrooney Stephen M SM   Gumaste Vivek V VV  

Case reports in gastroenterology 20180901 3

Ixekizumab is a selective monoclonal antibody targeting interleukin-17A, approved for the treatment of chronic plaque psoriasis. It has rarely been associated with inflammatory bowel disease (IBD) in randomized trials only. We report a unique case of severe new-onset ulcerative colitis in a young male complicated by cytomegalovirus infection who was on ixekizumab therapy for plaque psoriasis. We recommend that clinicians should exercise caution before prescribing ixekizumab as it seems to induce  ...[more]

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