Ontology highlight
ABSTRACT:
SUBMITTER: Lim CH
PROVIDER: S-EPMC6249328 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Lim Chae Ho CH Sun Qi Q Ratti Karan K Lee Soung-Hoon SH Zheng Ying Y Takeo Makoto M Lee Wendy W Rabbani Piul P Plikus Maksim V MV Cain Jason E JE Wang David H DH Watkins D Neil DN Millar Sarah S Taketo M Mark MM Myung Peggy P Cotsarelis George G Ito Mayumi M
Nature communications 20181121 1
Mammalian wounds typically heal by fibrotic repair without hair follicle (HF) regeneration. Fibrosis and regeneration are currently considered the opposite end of wound healing. This study sought to determine if scar could be remodeled to promote healing with HF regeneration. Here, we identify that activation of the Sonic hedgehog (Shh) pathway reinstalls a regenerative dermal niche, called dermal papilla, which is required and sufficient for HF neogenesis (HFN). Epidermal Shh overexpression or ...[more]