HPV16 viral characteristics in primary, recurrent and metastatic vulvar carcinoma.
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ABSTRACT:
SUBMITTER: Lillsunde Larsson G
PROVIDER: S-EPMC6249404 | biostudies-other | 2018 Dec
REPOSITORIES: biostudies-other
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HPV16 viral characteristics in primary, recurrent and metastatic vulvar carcinoma.
Lillsunde Larsson Gabriella G Kaliff Malin M Sorbe Bengt B Helenius Gisela G Karlsson Mats G MG
Papillomavirus research (Amsterdam, Netherlands) 20181102
Vulvar carcinoma is the fourth most common gynecological malignancy. Two separate carcinogenic pathways are suggested, where one is associated with the human papillomavirus (HPV) and HPV16 the most common genotype. The aim of this study was to evaluate HPV-markers in a set of primary tumors, metastases and recurrent lesions of vulvar squamous cell carcinomas (VSCC). Ten HPV16-positive VSCC with metastatic regional lymph nodes, distant lymphoid/hematogenous metastases or local recurrent lesions w ...[more]
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