Ontology highlight
ABSTRACT:
SUBMITTER: Monda JK
PROVIDER: S-EPMC6249811 | biostudies-other | 2018 Sep
REPOSITORIES: biostudies-other
Monda Julie K JK Cheeseman Iain M IM
Molecular biology of the cell 20180719 19
Nde1 is a key regulator of cytoplasmic dynein, binding directly to both dynein itself and the dynein adaptor, Lis1. Nde1 and Lis1 are thought to function together to promote dynein function, yet mutations in each result in distinct neurodevelopment phenotypes. To reconcile these phenotypic differences, we sought to dissect the contribution of Nde1 to dynein regulation and explore the cellular functions of Nde1. Here we show that an Nde1-Lis1 interaction is required for spindle pole focusing and ...[more]