Ontology highlight
ABSTRACT:
SUBMITTER: Dolati S
PROVIDER: S-EPMC6249830 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Dolati Setareh S Kage Frieda F Mueller Jan J Müsken Mathias M Kirchner Marieluise M Dittmar Gunnar G Sixt Michael M Rottner Klemens K Falcke Martin M
Molecular biology of the cell 20180829 22
Lamellipodia are flat membrane protrusions formed during mesenchymal motion. Polymerization at the leading edge assembles the actin filament network and generates protrusion force. How this force is supported by the network and how the assembly rate is shared between protrusion and network retrograde flow determines the protrusion rate. We use mathematical modeling to understand experiments changing the F-actin density in lamellipodia of B16-F1 melanoma cells by modulation of Arp2/3 complex acti ...[more]