Indoxyl Sulphate is Associated with Atrial Fibrillation Recurrence after Catheter Ablation.

ABSTRACT: Renal dysfunction results in the accumulation of various uremic toxins, including indoxyl sulphate (IS), and is a major risk factor for atrial fibrillation (AF). Experimental studies have demonstrated that IS exacerbates atrial remodelling via oxidative stress, inflammation, and fibrosis. However, its clinical impact on AF-promoting cardiac remodelling has not been described. Therefore, the purpose of this study was to clarify the relationship between basal IS levels and the 1-year outcomes after catheter ablation for the treatment of AF. Our prospective observational study included data from 125 patients with AF who underwent catheter ablation. Over a 1-year follow-up period, AF recurrence was identified in 21 patients. The 1-year AF-free survival was significantly lower in patients with high serum IS levels (?0.65??g/mL) than in those with low IS levels (60.1?±?10.4% versus 85.2?±?3.9%, P?=?0.007). Univariable analysis identified that an IS concentration???0.65??g/mL was associated with AF recurrence (hazard ratio [HR]?=?3.10 [1.26-7.32], P?=?0.015), and this association was maintained in multivariate analysis (HR?=?3.67 [1.13-11.7], P?=?0.031). Thus, in patients undergoing AF ablation, serum IS levels at baseline independently predict the recurrence of arrhythmia.

SUBMITTER: Yamagami F 

PROVIDER: S-EPMC6250674 | biostudies-other | 2018 Nov

REPOSITORIES: biostudies-other