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Immunological bases of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia.


ABSTRACT: Malaria and anaemia are key underlying factors for iNTS disease in African children. Knowledge of clinical and epidemiological risk-factors for iNTS disease has not been paralleled by an in-depth knowledge of the immunobiology of the disease. Herein, we review human and animal studies on mechanisms of increased susceptibility to iNTS in children.

SUBMITTER: Nyirenda TS 

PROVIDER: S-EPMC6250906 | biostudies-other | 2018 Oct - Nov

REPOSITORIES: biostudies-other

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Immunological bases of increased susceptibility to invasive nontyphoidal Salmonella infection in children with malaria and anaemia.

Nyirenda Tonney S TS   Mandala Wilson L WL   Gordon Melita A MA   Mastroeni Pietro P  

Microbes and infection 20171215 9-10


Malaria and anaemia are key underlying factors for iNTS disease in African children. Knowledge of clinical and epidemiological risk-factors for iNTS disease has not been paralleled by an in-depth knowledge of the immunobiology of the disease. Herein, we review human and animal studies on mechanisms of increased susceptibility to iNTS in children. ...[more]

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