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Squalene emulsions for parenteral vaccine and drug delivery.


ABSTRACT: Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based products is also addressed. Finally, analytical techniques for characterization of squalene emulsions are examined.

SUBMITTER: Fox CB 

PROVIDER: S-EPMC6254918 | biostudies-other | 2009

REPOSITORIES: biostudies-other

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Squalene emulsions for parenteral vaccine and drug delivery.

Fox Christopher B CB  

Molecules (Basel, Switzerland) 20090901 9


Squalene is a linear triterpene that is extensively utilized as a principal component of parenteral emulsions for drug and vaccine delivery. In this review, the chemical structure and sources of squalene are presented. Moreover, the physicochemical and biological properties of squalene-containing emulsions are evaluated in the context of parenteral formulations. Historical and current parenteral emulsion products containing squalene or squalane are discussed. The safety of squalene-based product  ...[more]

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