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Design of antimicrobially active small amphiphilic peptide dendrimers.

ABSTRACT: Novel polyfunctional small amphiphilic peptide dendrimers characterized by incorporation of a new core compounds - tris-amino acids or tetrakis-amino alcohols that originated from a series of basic amino acids - were efficiently synthesized. These new core elements yielded molecules with multiple branching and (+5)/(+6) charge at the 1-st dendrimer generation. Dendrimers exhibited significant antimicrobial potency against Gram(+) and Gram(-) strains involving also multiresistant reference strains (S. aureus ATCC 43300 and E. coli ATCC BAA-198). In addition, high activity against fungi from the Candida genus was detected. More charged and more hydrophobic peptide dendrimers expressed hemolytic properties.

SUBMITTER: Polcyn P 

PROVIDER: S-EPMC6255327 | biostudies-other | 2009

REPOSITORIES: biostudies-other

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Design of antimicrobially active small amphiphilic peptide dendrimers.

Polcyn Piotr P   Jurczak Margarita M   Rajnisz Aleksandra A   Solecka Jolanta J   Urbanczyk-Lipkowska Zofia Z  

Molecules (Basel, Switzerland) 20090929 10

Novel polyfunctional small amphiphilic peptide dendrimers characterized by incorporation of a new core compounds - tris-amino acids or tetrakis-amino alcohols that originated from a series of basic amino acids - were efficiently synthesized. These new core elements yielded molecules with multiple branching and (+5)/(+6) charge at the 1-st dendrimer generation. Dendrimers exhibited significant antimicrobial potency against Gram(+) and Gram(-) strains involving also multiresistant reference strain  ...[more]