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Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study.


ABSTRACT: BACKGROUND:Negative coronary artery remodeling is frequent in patients with diabetes, but its mechanism remains unclear. We here evaluated the association of serum levels of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) with coronary artery remodeling in type 2 diabetic patients. METHODS:Serum levels of GA and esRAGE were measured and intravascular ultrasound was performed in 136 consecutive diabetic patients with 143 coronary intermediate lesions. The remodeling index (RI) was calculated as the ratio between external elastic membrane (EEM) area at the lesion site and EEM area at the reference segment. Negative remodeling (NR) was defined as an RI?

SUBMITTER: Du R 

PROVIDER: S-EPMC6258438 | biostudies-other | 2018 Nov

REPOSITORIES: biostudies-other

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Increased glycated albumin and decreased esRAGE levels in serum are related to negative coronary artery remodeling in patients with type 2 diabetes: an Intravascular ultrasound study.

Du Run R   Zhang Rui Yan RY   Lu Lin L   Shen Ying Y   Pu Li Jin LJ   Zhu Zheng Bin ZB   Zhang Qi Q   Hu Jian J   Yang Zhen Kun ZK   Ding Feng Hua FH   Zhang Jian Sheng JS   Shen Wei Feng WF  

Cardiovascular diabetology 20181127 1


<h4>Background</h4>Negative coronary artery remodeling is frequent in patients with diabetes, but its mechanism remains unclear. We here evaluated the association of serum levels of glycated albumin (GA) and endogenous secretory receptor for advanced glycation end products (esRAGE) with coronary artery remodeling in type 2 diabetic patients.<h4>Methods</h4>Serum levels of GA and esRAGE were measured and intravascular ultrasound was performed in 136 consecutive diabetic patients with 143 coronary  ...[more]

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