Ontology highlight
ABSTRACT:
SUBMITTER: Begarani F
PROVIDER: S-EPMC6266174 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Begarani Filippo F Cassano Domenico D Margheritis Eleonora E Marotta Roberto R Cardarelli Francesco F Voliani Valerio V
Nanomaterials (Basel, Switzerland) 20181101 11
Although conceptually obvious, the effective delivery of proteins in therapeutic applications is far from being a routine practice. The major limitation is the conservation of protein physicochemical identity during the transport to the target site. In this regard, nanoparticle-based systems offer new intriguing possibilities, provided that (i) the harsh and denaturating conditions typically used for nanoparticle synthesis are avoided or mitigated; and (ii) nanoparticle biocompatibility and degr ...[more]