Ontology highlight
ABSTRACT:
SUBMITTER: Harhala M
PROVIDER: S-EPMC6266847 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Harhala Marek M Nelson Daniel C DC Miernikiewicz Paulina P Heselpoth Ryan D RD Brzezicka Beata B Majewska Joanna J Linden Sara B SB Shang Xiaoran X Szymczak Aleksander A Lecion Dorota D Marek-Bukowiec Karolina K Kłak Marlena M Wojciechowicz Bartosz B Lahutta Karolina K Konieczny Andrzej A Dąbrowska Krystyna K
Viruses 20181115 11
Bacteriophage-derived endolysins have gained increasing attention as potent antimicrobial agents and numerous publications document the in vivo efficacy of these enzymes in various rodent models. However, little has been documented about their safety and toxicity profiles. Here, we present preclinical safety and toxicity data for two pneumococcal endolysins, Pal and Cpl-1. Microarray, and gene profiling was performed on human macrophages and pharyngeal cells exposed to 0.5 µM of each endolysin f ...[more]