Ontology highlight
ABSTRACT:
SUBMITTER: Reddy KR
PROVIDER: S-EPMC6269844 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Molecules (Basel, Switzerland) 20130910 9
The iodine-catalyzed Prins cyclization of homoallylic alcohols and aldehydes was investigated under metal-free conditions and without additives. Anhydrous conditions and inert atmosphere are not required. The reaction of 2-(3,4-dihydronaphthalen-1-yl)propan-1-ol and 21 aldehydes (aliphatic and aromatic) in CH₂Cl₂ in the presence of 5 mol % of iodine gave 1,4,5,6-tetrahydro-2H-benzo[f]isochromenes in 54%-86% yield. Under similar conditions, the Prins cyclization of six alcohols containing an endo ...[more]