Ontology highlight
ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC6271259 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Xu Libao L Zhang Yang Y Dai Wenjie W Wang Ying Y Jiang Dan D Wang Lili L Xiao Junhai J Yang Xiaohong X Li Song S
Molecules (Basel, Switzerland) 20140321 3
The design, synthesis and structure-activity relationship studies of some novel trisubstituted pyrimidine amide derivatives prepared as CCR4 antagonists are described. The activities of these compounds were evaluated by the CCR4-MDC chemotaxis inhibition assay. Compound 1, which we have previously reported as a potent antagonist of CCR4, was employed as the positive control. The results indicated that most of the synthesized compounds exhibited some chemotaxis inhibition activity against CCR4. O ...[more]