Ontology highlight
ABSTRACT:
SUBMITTER: Jeong YC
PROVIDER: S-EPMC6272196 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Molecules (Basel, Switzerland) 20150220 3
The synthesis, tautomerism and antibacterial activity of novel barbiturates is reported. In particular, 3-acyl and 3-carboxamidobarbiturates exhibited antibacterial activity, against susceptible and some resistant Gram-positive strains of particular interest is that these systems possess amenable molecular weight, rotatable bonds and number of proton-donors/acceptors for drug design as well as less lipophilic character, with physicochemical properties and ionic states that are similar to current ...[more]