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Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides.

ABSTRACT: Aralia chinensis var. dasyphylloides is widely distributed in China and used as a traditional herbal medicine for the treatment of digestive and immune system diseases. The present study aimed to search for novel oleanolic-type triterpenoids in low-polarity fractions. Six new triterpene derivatives (1-6), together with two known compounds were isolated from the barks of A. chinensis var. dasyphylloides. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and chemical methods. They were identified as 3-oxo-oleana-11,13(18)-dien-28,30-dioic acid (1), 30-hydroxy-3-oxo-oleana-11,13(18)-dien-28-oic acid (2), 3?-hydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-?-d-glucopyranoside (3), 3?,30-dihydroxy-oleana-11,13(18)-dien-28-oic acid-28-O-?-d-glucopyranoside (4), 3?-hydroxy-oleana-11,13(18)-dien-28-oic acid-3-O-?-d-xylopyranosyl-(1 ? 2)-?-d-glucopyranoside (5), 3?,29-dihydroxy-oleana-9(11),12-dien-28-oic acid-28-O-?-d-glucopyranoside (6), namely, araliachinolic acids I and II and araliachinosides I-IV. The cytotoxicity of the isolated compounds was tested against HepG2, A549, SGC7901, and MCF7 cell lines, but no apparent activity was observed at a concentration of 50 ?M.

SUBMITTER: Gao RX

PROVIDER: S-EPMC6273084 | biostudies-other | 2016 Dec

REPOSITORIES: biostudies-other

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Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides.

Gao Rui-Xi RX Liao Maochuan M Huang Xianju X Chen Yu Y Yang Guangzhong G Li Jun J

Molecules (Basel, Switzerland) 20161209 12

Aralia chinensis var. dasyphylloides is widely distributed in China and used as a traditional herbal medicine for the treatment of digestive and immune system diseases. The present study aimed to search for novel oleanolic-type triterpenoids in low-polarity fractions. Six new triterpene derivatives (1-6), together with two known compounds were isolated from the barks of A. chinensis var. dasyphylloides. Their structures were elucidated by 1D- and 2D-NMR ...[more]

PMID: 27941689

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Project description:BackgroundKiwifruit (Actinidia chinensis var. Chinensis) is abundant with vitamin C and is a rapidly developing crop in China, New Zealand, and other countries. It has been widely used as a raw material for food and kiwifruit wine. Among these, A. chinensis var. chinensis and A. chinensis var. deliciosa are the most valuable kiwifruit in production. Kiwifruit is a typical dioecious plant and its female and male plants have different economic values. Therefore, sex identification, especially at the seedling stage, has important implications for the scientific planning of its production and economic benefits. However, the kiwifruit sex regulation mechanism is very complex and molecular studies are in the initial stages. Currently, there is not a universal and effective sex identification method for A. chinensis.MethodsIn this study, we used a label-free quantitative proteomics approach to investigate differentially accumulated proteins, including their presence/absence and significantly different levels of abundances during A. chinensis var. chinensis male and female flower bud development.ResultsA total of 6485 proteins were identified, among which, 203 were identified in male buds, which were mainly associated with phenylalanine metabolism, tyrosine metabolism, and plant hormone signal transduction. In female buds, 241 were identified, which were mainly associated with the ErbB signaling pathway, growth hormone synthesis, secretion and action, and mRNA surveillance pathway. A total of 373 proteins were significantly differentially accumulated proteins (fold change > 2; P < 0.05), of which, 168 were upregulated and 205 were downregulated. Significant differences between proteins involved 13 signaling pathways, most of which were involved in flavonoid biosynthesis, phenylpropanoid biosynthesis, and starch and sucrose metabolism. Protein interaction analysis showed that enriched protein nodes included cell division cycle 5-like protein, 40S ribosomal protein S8, ribosomal protein, and 40S ribosomal protein like, which interact with 35, 25, 22, and 22 proteins, respectively.ConclusionsThis study provide valuable information for cloning key genes that control sex traits and functionally analyze their roles, which lay a foundation to the development of molecular markers for male and female kiwifruit identification.

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Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides.

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Six New Triterpene Derivatives from Aralia chinensis Var. dasyphylloides.

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