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Indole Alkaloids from the Leaves of Nauclea officinalis.

ABSTRACT: Three new indole alkaloids, named naucleamide G (1), and nauclealomide B and C (5 and 6), were isolated from the n-BuOH-soluble fraction of an EtOH extract of the leaves of Nauclea officinalis, together with three known alkaloids, paratunamide C (2), paratunamide D (3) and paratunamide A (4). The structures with absolute configurations of the new compounds were identified on the basis of 1D and 2D NMR, HRESIMS, acid hydrolysis and quantum chemical circular dichroism (CD) calculation. According to the structures of isolated indole alkaloids, their plausible biosynthetic pathway was deduced.

SUBMITTER: Fan L

PROVIDER: S-EPMC6273496 | biostudies-other | 2016 Jul

REPOSITORIES: biostudies-other

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Indole Alkaloids from the Leaves of Nauclea officinalis.

Fan Long L Liao Cheng-Hui CH Kang Qiang-Rong QR Zheng Kai K Jiang Ying-Chun YC He Zhen-Dan ZD

Molecules (Basel, Switzerland) 20160723 8

Three new indole alkaloids, named naucleamide G (1), and nauclealomide B and C (5 and 6), were isolated from the n-BuOH-soluble fraction of an EtOH extract of the leaves of Nauclea officinalis, together with three known alkaloids, paratunamide C (2), paratunamide D (3) and paratunamide A (4). The structures with absolute configurations of the new compounds were identified on the basis of 1D and 2D NMR, HRESIMS, acid hydrolysis and quantum chemical circular dichroism (CD) calculation. According t ...[more]

PMID: 27455233

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