Ontology highlight
ABSTRACT:
SUBMITTER: Matthews JD
PROVIDER: S-EPMC6275846 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Matthews Jason D JD Reedy April R AR Wu Huixia H Hinrichs Benjamin H BH Darby Trevor M TM Addis Caroline C Robinson Brian S BS Go Young-Mi YM Jones Dean P DP Jones Rheinallt M RM Neish Andrew S AS
Redox biology 20181122
Intestinal homeostasis is regulated in-part by reactive oxygen species (ROS) that are generated in the colonic mucosa following contact with certain lactobacilli. Mechanistically, ROS can modulate protein function through the oxidation of cysteine residues within proteins. Recent advances in cysteine labeling by the Isotope Coded Affinity Tags (ICATs) technique has facilitated the identification of cysteine thiol modifications in response to stimuli. Here, we used ICATs to map the redox protein ...[more]