Ontology highlight
ABSTRACT:
SUBMITTER: Du Y
PROVIDER: S-EPMC6275874 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Du Yong Y Du Zhao Z Zheng Hongping H Wang Dan D Li Shifeng S Yan Yuanchang Y Li Yiping Y
Cellular & molecular biology letters 20130221 2
γ-amino butyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA is also found in many peripheral tissues, where it has important functions during development. Here, we identified the existence of the GABA system in spermatogonial stem cells (SSCs) and found that GABA negatively regulates SSC proliferation. First, we demonstrated that GABA and its synthesizing enzymes were abundant in the testes 6 days postpartum (dpp), suggesting that GABA signal ...[more]