Ontology highlight
ABSTRACT:
SUBMITTER: Tawk C
PROVIDER: S-EPMC6276891 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Tawk Caroline C Nigro Giulia G Rodrigues Lopes Ines I Aguilar Carmen C Lisowski Clivia C Mano Miguel M Sansonetti Philippe P Vogel Jörg J Eulalio Ana A
The EMBO journal 20181102 23
While mucosal inflammation is a major source of stress during enteropathogen infection, it remains to be fully elucidated how the host benefits from this environment to clear the pathogen. Here, we show that host stress induced by different stimuli mimicking inflammatory conditions strongly reduces the binding of <i>Shigella flexneri</i> to epithelial cells. Mechanistically, stress activates acid sphingomyelinase leading to host membrane remodeling. Consequently, knockdown or pharmacological inh ...[more]