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Data highlighting the expression of two miR-132/212 target genes-Sirt1 and Pten-after chronic stress.


ABSTRACT: The data presented here are related to our research article entitled "miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior" (Aten et al., 2018). In this article, we utilize immunofluorescent techniques to examine the protein-level expression of two microRNA-132/212 target genes, Sirt1 and Pten, in miR-132 transgenic and miR-132/212 conditional knockout (cKO) mouse lines. Additionally, using immunohistochemistry, we detail the expression profile of Sirt1 and Pten in the hippocampus and amygdala of WT mice after a 15?day chronic restraint stress paradigm.

SUBMITTER: Aten S 

PROVIDER: S-EPMC6279806 | biostudies-other | 2018 Dec

REPOSITORIES: biostudies-other

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Data highlighting the expression of two miR-132/212 target genes-Sirt1 and Pten-after chronic stress.

Aten Sydney S   Page Chloe E CE   Kalidindi Anisha A   Wheaton Kelin L KL   Niraula Anzela A   Godbout Jon P JP   Hoyt Kari R KR   Obrietan Karl K  

Data in brief 20181113


The data presented here are related to our research article entitled "miR-132/212 is induced by stress and its dysregulation triggers anxiety-related behavior" (Aten et al., 2018). In this article, we utilize immunofluorescent techniques to examine the protein-level expression of two microRNA-132/212 target genes, <i>Sirt1</i> and <i>Pten</i>, in miR-132 transgenic and miR-132/212 conditional knockout (cKO) mouse lines. Additionally, using immunohistochemistry, we detail the expression profile o  ...[more]

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